Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …

Cancer cells proliferate, differentiate and migrate by repurposing physiological signalling
mechanisms. In particular, altered calcium signalling is emerging as one of the most …

Breast cancer is one of the most frequent cancer types worldwide and the first cause of
cancer-related deaths in women. Although significant therapeutic advances have been …

Increased expression of the TRPM 4 channel has been reported to be associated with the
progression of prostate cancer. However, the molecular mechanism underlying its effect …

Transient receptor potential melastatin 4 (TRPM4) is widely expressed in various organs
and associated with cardiovascular and immune diseases. Lately, the interest in studies on …

Background and Purpose TRPM4 is a calcium‐activated non‐selective cation channel
expressed in many tissues and implicated in several diseases, and has not yet been …

Abstract Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca2+‐activated and voltage‐
dependent monovalent cation channel, which depolarizes the plasma cell membrane …

Ion channels form an important class of drug targets in malignancies. Transient receptor
potential cation channel subfamily M member 4 (TRPM4) plays oncological roles in various …

Transient receptor potential melastatin‐4 channel (TRPM4) dysregulation contributes to
heart conditions, immune diseases, and cervical and prostate cancer. Up to now, the …

The TRPM4 channel has been extensively studied in cerebral diseases such as stroke,
head injury and multiple sclerosis. In the heart, gain-of-function mutations of TRPM4 are a …