Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

In mammals, the neuroendocrine system, which includes the communication between the
hypothalamus and the pituitary, plays a major role in controlling body growth and cellular …

Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-
1), declines over time until only low levels can be detected in individuals aged≥ 60 years …

Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we
will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its …

The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination,
genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been …

IGF-1 is a growth-promoting polypeptide that is essential for normal growth and
development. In serum, the majority of the IGFs exist in a 150-kDa complex including the IGF …

Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein
degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term …

Insulin-like growth factor-I (IGF-I) is closely related to insulin but has distinct metabolic
actions. IGF-I is an important stimulant of protein synthesis in muscle, but it also stimulates …

The vascular insulin-like growth factor (IGF)-1 system includes the IGFs, the IGF-1 receptor
(IGF-1R), and multiple binding proteins. This growth factor system exerts multiple …

Adult growth hormone deficiency (GHD) is characterized by metabolic abnormalities
associated with visceral obesity, impaired quality of life, and increased mortality. Patients …