Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Malaria in pregnancy: pathogenesis and immunity

SJ Rogerson, L Hviid, PE Duffy, RFG Leke… - The Lancet infectious …, 2007 - thelancet.com
Understanding of the biological basis for susceptibility to malaria in pregnancy was recently
advanced by the discovery that erythrocytes infected with Plasmodium falciparum …

[HTML][HTML] Plasmodium falciparum Erythrocyte Membrane Protein 1 Diversity in Seven Genomes – Divide and Conquer

TS Rask, DA Hansen, TG Theander… - PLoS computational …, 2010 - journals.plos.org
The var gene encoded hyper-variable Plasmodium falciparum erythrocyte membrane
protein 1 (PfEMP1) family mediates cytoadhesion of infected erythrocytes to human …

Immune effector mechanisms in malaria

K Marsh, S Kinyanjui - Parasite immunology, 2006 - Wiley Online Library
That humans in endemic areas become immune to malaria offers encouragement to the
idea of developing protective vaccines. However natural immunity is relatively inefficient …

[PDF][PDF] Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

F Lennartz, Y Adams, A Bengtsson, RW Olsen… - Cell host & …, 2017 - cell.com
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …

Malaria's deadly grip: cytoadhesion of Plasmodium falciparum‐infected erythrocytes

JD Smith, JA Rowe, MK Higgins… - Cellular …, 2013 - Wiley Online Library
Cytoadhesion of P lasmodium falciparum‐infected erythrocytes to host microvasculature is a
key virulence determinant. Parasite binding is mediated by a large family of clonally variant …

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

T Lavstsen, L Turner, F Saguti… - Proceedings of the …, 2012 - National Acad Sciences
The clinical outcome of Plasmodium falciparum infections ranges from asymptomatic
parasitemia to severe malaria syndromes associated with high mortality. The virulence of P …

First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria

B Mordmüller, M Sulyok, D Egger-Adam… - Clinical Infectious …, 2019 - academic.oup.com
Background Malaria in pregnancy has major impacts on mother and child health. To
complement existing interventions, such as intermittent preventive treatment and use of …

[HTML][HTML] Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

MD Larsen, M Lopez-Perez, EK Dickson… - Nature …, 2021 - nature.com
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate
receptor-and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody …

[HTML][HTML] Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates

JA Chan, FJI Fowkes, JG Beeson - Cellular and Molecular Life Sciences, 2014 - Springer
Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …