As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol
and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of …

Cholesterol is a fundamental molecule necessary for the maintenance of cell structure and is
vital to various normal biological functions. It is a key factor in lifestyle-related diseases …

Background Cancer is emerging as a major problem globally, as it accounts for the second
cause of death despite medical advances. According to epidemiological and basic studies …

Simple Summary Statins are crucial for managing lipid disorders by inhibiting HMG-CoA
reductase, reducing cholesterol levels, and lowering cardiovascular disease risk. Beyond …

Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has a crucial role in lipid metabolism,
particularly due to its function in low‐density lipoprotein receptor degradation. Gain‐of …

Hypercholesterolemia has been documented to drive hormone-dependent breast cancer
(BC) progression and resistance to hormonal therapy. Proprotein convertase subtilisin/kexin …

Background Disulfidptosis is a type of programmed cell death caused by excessive cysteine-
induced disulfide bond denaturation leading to actin collapse. Liver cancer has a poor …

Cholesterol plays an important role in cellular homeostasis by maintaining the rigidity of cell
membranes, providing a medium for signaling transduction, and being converted into other …

Background Esophageal cancer often appears as postoperative metastasis or recurrence
after radical surgery. Although we had previously reported that serum programmed cell …