[HTML][HTML] Hyperinsulinemia in obesity, inflammation, and cancer

AMY Zhang, EA Wellberg, JL Kopp… - Diabetes & metabolism …, 2021 - ncbi.nlm.nih.gov
The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

Diabetes mellitus and prognosis in women with breast cancer: a systematic review and meta-analysis

XB Zhao, GS Ren - Medicine, 2016 - journals.lww.com
Background: Diabetes mellitus is associated with an increased risk of breast cancer, but
studies of the effects of diabetes on the prognosis of women with breast cancer have yielded …

Metformin increases survival in hormone receptor-positive, HER2-positive breast cancer patients with diabetes

HJ Kim, H Kwon, JW Lee, HJ Kim, SB Lee… - Breast Cancer …, 2015 - Springer
Introduction Metformin use has recently been observed to decrease both the rate and
mortality of breast cancer. Our study was aim to determine whether metformin use is …

[HTML][HTML] Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumor-associated miRNAs in breast and …

B Bao, AS Azmi, S Ali, F Zaiem… - Annals of translational …, 2014 - ncbi.nlm.nih.gov
Metformin is one of the most used diabetic drugs for the management of type II diabetes
mellitus (DM) in the world. Increased numbers of epidemiological and clinical studies have …

[HTML][HTML] Type 2 diabetes and breast cancer: the interplay between impaired glucose metabolism and oxidant stress

P Ferroni, S Riondino, O Buonomo… - … medicine and cellular …, 2015 - hindawi.com
Metabolic disorders, especially type 2 diabetes and its associated complications, represent
a growing public health problem. Epidemiological findings indicate a close relationship …

Diabetes and overall survival among breast cancer patients in the US military health system

S Shao, AA Gill, SH Zahm, I Jatoi, CD Shriver… - … Biomarkers & Prevention, 2018 - AACR
Background: Although research suggests that type II diabetes mellitus (DM-2) is associated
with overall and breast cancer–specific decreased survival, most prior studies of breast …

The epidemiology and molecular mechanisms linking obesity, diabetes, and cancer

RD Ferguson, EJ Gallagher, EJ Scheinman… - Vitamins & …, 2013 - Elsevier
The worldwide epidemic of obesity is associated with increasing rates of the metabolic
syndrome and type 2 diabetes. Epidemiological studies have reported that these conditions …

Type 2 diabetes, breast cancer specific and overall mortality: Associations by metformin use and modification by race, body mass, and estrogen receptor status

KN Lee, MA Torres, AN Troeschel, J He, K Gogineni… - PLoS …, 2020 - journals.plos.org
Introduction While type 2 diabetes (T2D) has been associated with increased all-cause
mortality among women diagnosed with breast cancer (BC), the association between T2D …

Metformin use and survival after non‐small cell lung cancer: A cohort study in the US Military health system

J Lin, A Gill, SH Zahm, CA Carter… - … journal of cancer, 2017 - Wiley Online Library
Research suggests that metformin may be associated with improved survival in cancer
patients with type II diabetes. This study assessed whether metformin use after non‐small …

The effect of metformin on breast cancer outcomes in patients with type 2 diabetes

BA Oppong, LA Pharmer, S Oskar, A Eaton… - Cancer …, 2014 - Wiley Online Library
Observational data suggest that metformin use decreases breast cancer (BC) incidence in
women with diabetes; the impact of metformin on BC outcomes in this population is less …