DNA topoisomerases are nature's tools for resolving the unique problems of DNA
entanglement that occur owing to unwinding and rewinding of the DNA helix during …

DNA topoisomerases are a diverse set of essential enzymes responsible for maintaining
chromosomes in an appropriate topological state. Although they vary considerably in …

Meiotic recombination is induced by the formation of DNA double-strand breaks (DSBs)
catalyzed by SPO11, the ortholog of subunit A of TopoVI DNA topoisomerase (TopoVIA) …

Viruses infecting cells from the three domains of life, Archaea, Bacteria and Eukarya, share
homologous features, suggesting that viruses originated very early in the evolution of life …

Meiotic recombination is carried out through a specialized pathway for the formation and
repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal …

▪ Abstract Topoisomerases are enzymes that use DNA strand scission, manipulation, and
rejoining activities to directly modulate DNA topology. These actions provide a powerful …

The DNA topoisomerases are essential for DNA replication, transcription, recombination, as
well as for chromosome compaction and segregation. They may have appeared early during …

Type II topoisomerases disentangle DNA to facilitate chromosome segregation, and
represent a major class of therapeutic targets. Although these enzymes have been studied …

The significant role of topoisomerases in the control of DNA chain topology has been
confirmed in numerous research conducted worldwide. The prevalence of these enzymes …

The Spo11 protein is a eukaryotic homologue of the archaeal DNA topoisomerase VIA
subunit (topo VIA). In archaea it is involved, together with its B subunit (topo VIB), in DNA …