[HTML][HTML] Type I interferons in infectious disease

F McNab, K Mayer-Barber, A Sher, A Wack… - Nature Reviews …, 2015 - nature.com
Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

Ten strategies of interferon evasion by viruses

A García-Sastre - Cell host & microbe, 2017 - cell.com
Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral
response to replicate and propagate to new hosts. The complex regulation of the IFN …

m6A modification controls the innate immune response to infection by targeting type I interferons

R Winkler, E Gillis, L Lasman, M Safra, S Geula… - Nature …, 2019 - nature.com
Abstract N6-methyladenosine (m6A) is the most common mRNA modification. Recent
studies have revealed that depletion of m6A machinery leads to alterations in the …

[HTML][HTML] Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection

KC Bradley, K Finsterbusch, D Schnepf, S Crotta… - Cell reports, 2019 - cell.com
Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while
minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying …

Zika virus targets human STAT2 to inhibit type I interferon signaling

A Grant, SS Ponia, S Tripathi, V Balasubramaniam… - Cell host & …, 2016 - cell.com
The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as
emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome …

Biology of the TAM receptors

G Lemke - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead …

Viral mutation rates

R Sanjuán, MR Nebot, N Chirico, LM Mansky… - Journal of …, 2010 - Am Soc Microbiol
Accurate estimates of virus mutation rates are important to understand the evolution of the
viruses and to combat them. However, methods of estimation are varied and often complex …

Oncolytic viruses and their application to cancer immunotherapy

EA Chiocca, SD Rabkin - Cancer immunology research, 2014 - AACR
Oncolytic viruses (OV) selectively replicate and kill cancer cells and spread within the tumor,
while not harming normal tissue. In addition to this direct oncolytic activity, OVs are also very …

Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity

M Dreux, U Garaigorta, B Boyd, E Décembre, J Chung… - Cell host & …, 2012 - cell.com
Viral nucleic acids often trigger an innate immune response in infected cells. Many viruses,
including hepatitis C virus (HCV), have evolved mechanisms to evade intracellular …

Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion

W Wang, G Li, D Wu, Z Luo, P Pan, M Tian… - Nature …, 2018 - nature.com
Zika virus (ZIKV) infection is a public health emergency and host innate immunity is essential
for the control of virus infection. The NLRP3 inflammasome plays a key role in host innate …