Non-alcoholic fatty liver disease (NAFLD) is a common disease, which is characterized by
the accumulation of triglycerides in the hepatocytes without excess alcohol intake. Circadian …

The daily rhythm of mammalian energy metabolism is subject to the circadian clock system,
which is made up of the molecular clock machinery residing in nearly all cells throughout the …

CCAAT/enhancer binding protein (C/EBP) β and C/EBPδ are transcription factors of the
basic-leucine zipper class which share phylogenetic, structural and functional features. In …

Daily physiological and behavioral rhythms are regulated by endogenous circadian
molecular clocks. Clock proteins DEC1 (BHLHe40) and DEC2 (BHLHe41) belong to the …

Jumonji domain-containing proteins (JMJD) catalyze the oxidative demethylation of a
methylated lysine residue of histones by using O 2, α-ketoglutarate, vitamin C, and Fe (II) …

Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is a
common risk factor for pulmonary arterial hypertension (PAH). As a hypoxia-induced …

The human gut is colonized by commensal microorganisms, predominately bacteria that
have coevolved in symbiosis with their host. The gut microbiota has been extensively …

While many genes specifically act as oncogenes or tumor suppressors, others are tumor
promoters or suppressors in a context-dependent manner. Here we will review the basic …

Hypoxic exercise may represent a novel therapeutic strategy to reduce and prevent obesity
through the regulation of lipid metabolism. During hypoxic exercise, the targeting of …

Overnutrition has gradually become the primary causative factor in nonalcoholic fatty liver
disease (NAFLD). However, how nutritional signals are integrated to orchestrate the …