MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As
one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed …

Micro-ribonucleic acids (miRNAs) are important class of short regulatory RNA molecules
involved in regulation of several essential biological processes. In addition to Dicer and …

Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle
apparatus. Centrosomes themselves duplicate once per cell cycle, in a process that is …

Immune evasion is a pivotal event in tumor progression. To eliminate human cancer cells,
current immune checkpoint therapy is set to boost CD8+ T cell–mediated cytotoxicity …

Amplification of chromosome 7p11 (7p11) is the most common alteration in primary
glioblastoma (GBM), resulting in gains of epidermal growth factor receptor (EGFR) copy …

Amongst the various types of cancer, breast cancer is a highly heterogeneous disease and
known as the leading cause of death among women globally. The extensive interdisciplinary …

Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease that features
colonic epithelial barrier dysfunction and gut dysbiosis. Preclinical studies demonstrated that …

The 17q23 amplicon is associated with poor outcome in ER+ breast cancers, but the causal
genes to endocrine resistance in this amplicon are unclear. Here, we interrogate …

Trastuzumab is a standard molecular targeted therapy for human epidermal growth factor
receptor 2 (HER2)-positive breast cancer, which can significantly improve the survival of …

Aurora-A kinase interacting protein 1 (AURKAIP1) has been proved to take an intermediary
role in cancer by functioning as a negative regulator of Aurora-A kinase. However, it remains …