Background: von Willebrand disease (VWD) is the most common inherited bleeding disorder
known in humans. Accurate and timely diagnosis presents numerous challenges. Objective …

Von Willebrand factor (VWF) is a large and complex plasma glycoprotein that is essential for
normal haemostasis. It is well recognized that deficiency of VWF results in a bleeding …

The management of perioperative bleeding involves multiple assessments and strategies to
ensure appropriate patient care. Initially, it is important to identify those patients with an …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

The guideline writing group was selected to be representative of UK‐based medical experts.
MEDLINE was systematically searched for publications in English up to the Summer of 2010 …

Although rare, the prevalence of inherited platelet function disorders (IPFD) is probably
underestimated due to under‐diagnosis 1. IPFD are heterogeneous in severity, mechanisms …

Background Diagnosis of inherited platelet function disorders (IPFDs) is important for
appropriate management and to improve epidemiologic and clinical knowledge. However …

Variations in platelet number, volume, and function are largely genetically controlled, and
many loci associated with platelet traits have been identified by genome-wide association …

Background Careful assessment of bleeding history is the first step in the evaluation of
patients with mild/moderate bleeding disorders, and the use of a bleeding assessment tool …

Background Heritable bleeding and platelet disorders (BPD) are heterogeneous and
frequently have an unknown genetic basis. The BRIDGE-BPD study aims to discover new …