Affinity reagents are essential tools in both basic and applied research; however, there is a
growing concern about the reproducibility of animal-derived monoclonal antibodies. The …

There is growing interest in using antibodies as auxiliary tools to crystallize proteins. Here
we describe a general protocol for the generation of Nanobodies to be used as …

In vitro selection of antibodies allows to obtain highly functional binders, rapidly and at lower
cost. Here, we describe the first fully synthetic phage display library of humanized llama …

To interfere with cell function, many scientists rely on methods that target DNA or RNA due to
the ease with which they can be applied. Proteins are usually the final executors of function …

Simple Summary Rhabdomyosarcoma (RMS) accounts for more than 50% of all soft tissue
sarcomas in childhood and adolescence. Despite progress and intensified multimodality …

Background Genomic, transcriptomic and proteomic projects often suffer from a lack of
functional validation creating a strong demand for specific and versatile antibodies. Antibody …

Botulinum neurotoxin (BoNT) serotype E is one of three serotypes that cause the
preponderance of human botulism cases and is a Tier 1 Select Agent. BoNT/E is unusual …

DNA has been used to build nanomachines with potential in cellulo and in vivo applications.
However their different in cellulo applications are limited by the lack of generalizable …

We describe a phage display approach that we have previously used to generate
conformation-sensor antibodies that specifically recognize and stabilize the oxidized …

Recent reports on the hitherto underestimated antigenicity of poly (ethylene glycol)(PEG),
which is widely used for pharmaceutical applications, highlight the need for efficient testing …