Skeletal muscle fibrosis: an overview
MAA Mahdy - Cell and tissue research, 2019 - Springer
Extracellular matrix (ECM) is an essential component of skeletal muscle. It provides a
framework structure that holds myofibers and blood capillaries and nerves supplying the …
framework structure that holds myofibers and blood capillaries and nerves supplying the …
Histological methods to assess skeletal muscle degeneration and regeneration in Duchenne muscular dystrophy
N Dubuisson, R Versele, C Planchon… - International journal of …, 2022 - mdpi.com
Duchenne muscular dystrophy (DMD) is a progressive disease caused by the loss of
function of the protein dystrophin. This protein contributes to the stabilisation of striated cells …
function of the protein dystrophin. This protein contributes to the stabilisation of striated cells …
Transdermal drug delivery via microneedles for musculoskeletal systems
H Zheng, X Xie, H Ling, X You, S Liang, R Lin… - Journal of Materials …, 2023 - pubs.rsc.org
As the population is ageing and lifestyle is changing, the prevalence of musculoskeletal
(MSK) disorders is gradually increasing with each passing year, posing a serious threat to …
(MSK) disorders is gradually increasing with each passing year, posing a serious threat to …
Unraveling muscle impairment associated with COVID-19 and the role of 3D culture in its investigation
MLGA Seixas, LP Mitre, S Shams, GB Lanzuolo… - Frontiers in …, 2022 - frontiersin.org
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
been considered a public health emergency, extensively investigated by researchers …
been considered a public health emergency, extensively investigated by researchers …
Engineering an environment for the study of fibrosis: a 3D human muscle model with endothelium specificity and endomysium
The integration of vascular structures into in vitro cultured tissues provides realistic models
of complex tissue-vascular interactions. Despite the incidence and impact of muscle-wasting …
of complex tissue-vascular interactions. Despite the incidence and impact of muscle-wasting …
Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis
KM Stearns-Reider, MR Hicks, KG Hammond… - NPJ Regenerative …, 2023 - nature.com
We developed an on-slide decellularization approach to generate acellular extracellular
matrix (ECM) myoscaffolds that can be repopulated with various cell types to interrogate cell …
matrix (ECM) myoscaffolds that can be repopulated with various cell types to interrogate cell …
Muscle histological changes in a large cohort of patients affected with Becker muscular dystrophy
M Ripolone, D Velardo, S Mondello, S Zanotti… - Acta Neuropathologica …, 2022 - Springer
Becker muscular dystrophy (BMD) is a severe X-linked muscle disease. Age of onset,
clinical variability, speed of progression and affected tissues display wide variability, making …
clinical variability, speed of progression and affected tissues display wide variability, making …
Pharmacological mitigation of fibrosis in a porcine model of volumetric muscle loss injury
BT Corona, JC Rivera, KA Dalske… - … Engineering Part A, 2020 - liebertpub.com
Volumetric muscle loss (VML) resulting from extremity trauma presents functional deficits
and fibrosis, ultimately manifesting disability. The extensive fibrotic accumulation is expected …
and fibrosis, ultimately manifesting disability. The extensive fibrotic accumulation is expected …
Phagocytosis mediated by scavenger receptor class BI promotes macrophage transition during skeletal muscle regeneration
J Zhang, C Qu, T Li, W Cui, X Wang, J Du - Journal of Biological Chemistry, 2019 - ASBMB
Macrophages play an essential role in skeletal muscle regeneration. The phagocytosis of
muscle cell debris induces a switch of pro-inflammatory macrophages into an anti …
muscle cell debris induces a switch of pro-inflammatory macrophages into an anti …
Tuning macrophage phenotype to mitigate skeletal muscle fibrosis
Myeloid cells are critical to the development of fibrosis following muscle injury; however, the
mechanism of their role in fibrosis formation remains unclear. In this study, we demonstrate …
mechanism of their role in fibrosis formation remains unclear. In this study, we demonstrate …