Despite the tremendous advances in cancer treatment, resistance to chemotherapeutic
agents impedes higher success rates and accounts for major relapses in cancer therapy …

Abstract Non-communicable diseases (NCDs), also known as chronic diseases, are long-
lasting conditions that affect millions of people around the world. Different factors contribute …

Osteosarcoma (OS) is the most common bone malignancy and preferably occurs in children
and adolescents. Despite significant advances in surgery and chemotherapy for OS over the …

Osteosarcoma (OS) is the most common primary bone malignancy, mainly affecting children
and adolescents. Currently, surgical resection combined with adjuvant chemotherapy has …

Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. It
is a highly aggressive tumor with a tendency to spread to the lungs, which are the most …

Osteosarcoma (OS) is a pediatric malignant bone tumor that predominantly affects
adolescent and young adults. It has high risk for relapse and over the last four decades no …

Over the last 40 years osteosarcoma (OS) survival has stagnated with patients commonly
resistant to neoadjuvant MAP chemotherapy involving high dose methotrexate, adriamycin …

Ionizing radiation (IR) is an important cancer treatment approach. However, radioresistance
eventually occurs, resulting in poor outcomes in patients with cancer. Radioresistance is …

Background Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in
children and adolescents. The current treatment approach includes neoadjuvant and …

Background Non-small cell lung carcinoma (NSCLC) is often fatal; advanced NSCLC has a
5-year survival rate less than 20%. Platinum-based chemotherapy, in particular, cis …