Classic psychedelics refer to substances such as lysergic acid diethylamide (LSD),
psilocybin, ayahuasca, and mescaline, which induce altered states of consciousness by …

Alcoholism (alcohol dependence) is characterized by a compulsion to seek and ingest
alcohol (ethanol), loss of control over intake, and the emergence of a negative emotional …

Alcohol-dependent patients commonly show impairments in executive functions that
facilitate craving and can lead to relapse. However, the molecular mechanisms leading to …

The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …

Rationale Early-life events can cause long-term neurobiological and behavioural changes
with a resultant effect upon reward and addiction processes that enhance risk to develop …

Abstract Background The National Institute on Drug Abuse (NIDA) recently released a
Request for Information (RFI) soliciting comments on nonhuman animal models of …

Herein, we have reviewed the role of glutamate, the major excitatory neurotransmitter in the
brain, in a number of neurochemical,-physiological, and-behavioral processes mediating the …

Alcohol and drug dependence are serious public health problems worldwide. The
prevalence of alcohol and drug dependence in the United States and other parts of the …

Rationale Despite epidemiological and clinical data indicating marked gender differences in
alcohol use disorders (AUDs), few preclinical studies have examined sex differences in …

Alcohol and drug abuse take a large toll on society and affected individuals. However, very
few effective treatments are currently available to treat alcohol and drug addiction. Basic and …