Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

The DNA replication process needs to be coordinated with other DNA metabolism
transactions and must eventually extend to the full genome, regardless of chromatin status …

Micronuclei (MN) form from missegregated chromatin that recruits its own nuclear envelope
during mitotic exit and are a common consequence of chromosomal instability. MN are …

ATR takes a crack at the nuclear envelope: Molecular Cell Skip to Main Content Advertisement
Molecular Cell This journal offers authors two options (open access or subscription) to publish …

The family of cell cycle-dependent kinases (CDKs) serves as catalytic subunits within protein
kinase complexes, playing a crucial role in cell cycle progression. While the function of CDK …

Background and purpose Ionizing radiation (IR) induces DNA double-strand breaks (DSBs),
leading to micronuclei formation, which has emerged as a key mediator of inflammatory …

Micronuclei (MN) are induced by various genotoxic stressors and amass nuclear-and
cytoplasmic-resident proteins, priming the cell for MN-driven signaling cascades. Here, we …