The continuum of aging and age-related diseases: common mechanisms but different rates
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
DNA methylation-based age clocks: From age prediction to age reversion
Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …
progressive decline in physiological functionality and enhanced disease vulnerability …
Epigenetic aging in major depressive disorder
Objective: Major depressive disorder is associated with an increased risk of mortality and
aging-related diseases. The authors examined whether major depression is associated with …
aging-related diseases. The authors examined whether major depression is associated with …
DNA methylation clocks and their predictive capacity for aging phenotypes and healthspan
T Bergsma, E Rogaeva - Neuroscience insights, 2020 - journals.sagepub.com
The number of age predictors based on DNA methylation (DNAm) profile is rising due to
their potential in predicting healthspan and application in age-related illnesses, such as …
their potential in predicting healthspan and application in age-related illnesses, such as …
Evidence for biological age acceleration and telomere shortening in COVID-19 survivors
A Mongelli, V Barbi, M Gottardi Zamperla… - International journal of …, 2021 - mdpi.com
The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst
cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine …
cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine …
DNA methylation in nonalcoholic fatty liver disease
J Hyun, Y Jung - International journal of molecular sciences, 2020 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a widespread hepatic disorder in the United
States and other Westernized countries. Nonalcoholic steatohepatitis (NASH), an advanced …
States and other Westernized countries. Nonalcoholic steatohepatitis (NASH), an advanced …
A systematic review and meta-analysis of environmental, lifestyle, and health factors associated with DNA methylation age
J Ryan, J Wrigglesworth, J Loong… - The Journals of …, 2020 - academic.oup.com
DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an
individual's chronological age and can predict their risk of age-related disease and mortality …
individual's chronological age and can predict their risk of age-related disease and mortality …
Epigenetic age acceleration changes 2 years after antiretroviral therapy initiation in adults with HIV: a substudy of the NEAT001/ANRS143 randomised trial
A Esteban-Cantos, J Rodríguez-Centeno, P Barruz… - The lancet HIV, 2021 - thelancet.com
Background DNA methylation-based estimators of biological age are reliable biomarkers of
the ageing process. We aimed to investigate a range of epigenetic ageing biomarkers in a …
the ageing process. We aimed to investigate a range of epigenetic ageing biomarkers in a …
Twelve-year neurocognitive decline in HIV is associated with comorbidities, not age: a CHARTER study
Modern antiretroviral therapy (ART) has increased longevity of people with HIV and shifted
the age distribution of the HIV pandemic upward toward that of the general population. This …
the age distribution of the HIV pandemic upward toward that of the general population. This …