Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …

Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …

Tumor Treating Fields (TTFields), an approved therapy for glioblastoma (GBM) and
malignant mesothelioma, employ noninvasive application of low-intensity, intermediate …

Cancer immunotherapy by immune checkpoint blockade has proven its great potential by
saving the lives of a proportion of late stage patients with immunogenic tumor types …

Glioblastoma (GBM) is the most common primary brain tumor in adults an carries and carries
a terrible prognosis. The current regiment of surgical resection, radiation, and chemotherapy …

Radiotherapy is a mainstay of glioblastoma (GBM) treatment; however, the development of
therapeutic resistance has hampered the efficacy of radiotherapy, suggesting that additional …

Complete resection of isocitrate dehydrogenase 1 (IDH1)(R132H) glioma is unfeasible and
the classic post‐surgical chemo/radiotherapy suffers from high recurrence and low survival …

Glioblastoma (GBM) is the most malignant and lethal intracranial tumor, with extremely
limited treatment options. Immunotherapy has been widely studied in GBM, but none can …

Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …

The lack of reliable predictive biomarkers to guide effective therapy is a major obstacle to the
advancement of therapy for high-grade gliomas, particularly glioblastoma (GBM), one of the …