Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of
terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They …

Nitric oxide, bicarbonate, natriuretic peptides (ANP, BNP and CNP), guanylins, uroguanylins
and guanylyl cyclase activating proteins (GCAPs) activate a family of enzymes variously …

For more than four decades, the cyclic nucleotides cyclic AMP (cAMP) and cyclic GMP
(cGMP) have been recognized as important signaling molecules within cells. Under normal …

Background RNA adenosine modifications, which are primarily mediated by “writer”
enzymes (RMWs), play a key role in epigenetic regulation in various biological processes …

By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine
monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their …

Importance of the field: For many cancers, there has been a shift from management with
traditional, nonspecific cytotoxic chemotherapies to treatment with molecule-specific …

Functional gastrointestinal disorders (FGIDs) and IBDs are two of the most prevalent
disorders of the GI tract and consume a significant proportion of healthcare resources …

Guanylin, uroguanylin, and the bacterial heat-stable enterotoxin (ST) peptides comprise a
new family of cyclic guanosine 3′-5′ monophosphate (cGMP)-regulating agonists. The …

Cyclic GMP is a ubiquitous second messenger that regulates a wide array of physiologic
processes such as blood pressure, long bone growth, intestinal fluid secretion …

Background & Aims: The most commonly lost gene products in colorectal carcinogenesis
include guanylin and uroguanylin, endogenous ligands for guanylyl cyclase C (GCC) …