Conspectus Protein biosynthesis is a central process in all living cells that is catalyzed by a
complex molecular machine─ the ribosome. This process is termed translation because the …

Azide‐modified nucleosides are important building blocks for RNA and DNA
functionalization by click chemistry based on azide‐alkyne cycloaddition. This has put …

The development of facile methods for conjugating relevant probes, ligands, or delivery
agents onto oligonucleotides (ONs) is highly desirable both for fundamental studies in …

The development of the sulfur (VI)–fluoride exchange (SuFEx) and modular diazotransfer
(MoDAT) reactions represent important milestones in the evolution of click chemistry …

Hydrolysis-resistant RNA-peptide conjugates that mimic peptidyl-tRNAs are frequently
needed for structural and functional studies of protein synthesis in the ribosome. Such …

Azides are versatile bioorthogonal reporter moieties that are commonly used for site-specific
labeling and functionalization of RNA to probe its biology. The preparation of azido modified …

The bio-orthogonal reaction is a type of reaction that can occur within a cell without
interfering with the active components of the cell. Bio-orthogonal reaction techniques have …

Ribonucleic acids (RNAs) play a vital role in living organisms. Many of their cellular
functions depend critically on chemical modification. Methods to modify RNA in a controlled …

The synthesis of 1′-azido C-nucleosides is described to expand the set of azide-
functionalized nucleosides for bioorthogonal applications and as potential antiviral drugs …

RNA modifications are highly conserved across all domains of life, suggesting an early
emergence and a fundamental role in cellular processes. The modification 3-(3-amino-3 …