Peering into tunneling nanotubes—The path forward

D Cordero Cervantes, C Zurzolo - The EMBO journal, 2021 - embopress.org
Abstract The identification of Tunneling Nanotubes (TNTs) and TNT‐like structures signified
a critical turning point in the field of cell‐cell communication. With hypothesized roles in …

Wiring through tunneling nanotubes–from electrical signals to organelle transfer

S Abounit, C Zurzolo - Journal of cell science, 2012 - journals.biologists.com
Tunneling nanotubes (TNTs) represent a subset of F-actin-based transient tubular
connections that allow direct communication between distant cells. Recent studies have …

Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells

T Saha, C Dash, R Jayabalan, S Khiste… - Nature …, 2022 - nature.com
Cancer progresses by evading the immune system. Elucidating diverse immune evasion
strategies is a critical step in the search for next-generation immunotherapies for cancer …

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

H Scheiblich, C Dansokho, D Mercan, SV Schmidt… - Cell, 2021 - cell.com
Microglia are the CNS resident immune cells that react to misfolded proteins through pattern
recognition receptor ligation and activation of inflammatory pathways. Here, we studied how …

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

X Wang, HH Gerdes - Cell Death & Differentiation, 2015 - nature.com
Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in
culture and in tissues. They mediate intercellular communication ranging from electrical …

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

J Pasquier, BS Guerrouahen, H Al Thawadi… - Journal of translational …, 2013 - Springer
Our vision of cancer has changed during the past decades. Indeed tumors are now
perceived as complex entities where tumoral and stromal components interact closely …

Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma

E Lou, S Fujisawa, A Morozov, A Barlas, Y Romin… - PloS one, 2012 - journals.plos.org
Tunneling nanotubes are long, non-adherent F-actin-based cytoplasmic extensions which
connect proximal or distant cells and facilitate intercellular transfer. The identification of …

Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes after ischemic‐like injury in hippocampal …

MG Nasoni, S Carloni, B Canonico… - Journal of Pineal …, 2021 - Wiley Online Library
Mitochondrial dysfunction is considered one of the hallmarks of ischemia/reperfusion injury.
Mitochondria are plastic organelles that undergo continuous biogenesis, fusion, and fission …

Role of connexin 43 in different forms of intercellular communication–gap junctions, extracellular vesicles and tunnelling nanotubes

TM Ribeiro-Rodrigues… - Journal of cell …, 2017 - journals.biologists.com
Communication is important to ensure the correct and efficient flow of information, which is
required to sustain active social networks. A fine-tuned communication between cells is vital …

Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions

S Valdebenito, S Malik, R Luu, O Loudig, M Mitchell… - Scientific reports, 2021 - nature.com
Cell-to-cell communication is essential for the development and proper function of
multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) …