Pharmacogenomics: current status and future perspectives
M Pirmohamed - Nature Reviews Genetics, 2023 - nature.com
Inter-individual variability in drug response, be it efficacy or safety, is common and likely to
become an increasing problem globally given the growing elderly population requiring …
become an increasing problem globally given the growing elderly population requiring …
Pharmacogenomics in practice: A review and implementation guide
Considerable efforts have been exerted to implement Pharmacogenomics (PGx), the study
of interindividual variations in DNA sequence related to drug response, into routine clinical …
of interindividual variations in DNA sequence related to drug response, into routine clinical …
Frequencies of pharmacogenomic alleles across biogeographic groups in a large-scale biobank
Pharmacogenomics (PGx) is an integral part of precision medicine and contributes to the
maximization of drug efficacy and reduction of adverse drug event risk. Accurate information …
maximization of drug efficacy and reduction of adverse drug event risk. Accurate information …
Economic evaluation of pharmacogenomic-guided antiplatelet treatment in Spanish patients suffering from acute coronary syndrome participating in the U-PGx …
MI Koufaki, V Fragoulakis, X Díaz-Villamarín… - Human Genomics, 2023 - Springer
Background Cardiovascular diseases and especially Acute Coronary Syndrome (ACS)
constitute a major health issue impacting millions of patients worldwide. Being a leading …
constitute a major health issue impacting millions of patients worldwide. Being a leading …
Circulating biomarkers instead of genotyping to establish metabolizer phenotypes
R Tremmel, U Hofmann, M Haag… - Annual Review of …, 2024 - annualreviews.org
Pharmacogenomics (PGx) enables personalized treatment for the prediction of drug
response and to avoid adverse drug reactions. Currently, PGx mainly relies on the genetic …
response and to avoid adverse drug reactions. Currently, PGx mainly relies on the genetic …
Clinical implementation of preemptive pharmacogenomics in psychiatry
Summary Background Pharmacogenomics (PGx) holds promise to revolutionize modern
healthcare. Although there are several prospective clinical studies in oncology and …
healthcare. Although there are several prospective clinical studies in oncology and …
Response to the FDA Decision Regarding DPYD Testing Prior to Fluoropyrimidine Chemotherapy
Fluoropyrimidine (FP) chemotherapy is associated with severe, life‐threatening toxicities,
particularly among patients who carry deleterious germline variants in the DPYD gene …
particularly among patients who carry deleterious germline variants in the DPYD gene …
Development and Bioequivalence of 3D‐Printed Medication at the Point‐of‐Care: Bridging the Gap Toward Personalized Medicine
M Lyousoufi, I Lafeber, D Kweekel… - Clinical …, 2023 - Wiley Online Library
Personalized medicine is currently hampered by the lack of flexible drug formulations.
Especially for pediatric patients, manual compounding of personalized drug formulations by …
Especially for pediatric patients, manual compounding of personalized drug formulations by …
The case for precision medicine in the prevention, diagnosis, and treatment of cardiometabolic diseases in low-income and middle-income countries
Cardiometabolic diseases are the leading preventable causes of death in most
geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic …
geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic …
Impact of pharmacogenomics in clinical practice
N Principi, K Petropulacos, S Esposito - Pharmaceuticals, 2023 - mdpi.com
Polymorphisms of genes encoding drug metabolizing enzymes and transporters can
significantly modify pharmacokinetics, and this can be associated with significant differences …
significantly modify pharmacokinetics, and this can be associated with significant differences …