Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Self-assembled peptide nanostructures have been increasingly exploited as functional
materials for applications in biomedicine and energy. The emergent properties of these …

Liquid–liquid phase separation (LLPS) of proteins into biomolecular condensates has
emerged as a fundamental principle underpinning cellular function and malfunction. Indeed …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

The rapid and direct detection of biomarkers in biofluids at clinically relevant concentrations
faces serious limitations to develop diagnostic criteria for neurodegenerative diseases such …

In Alzheimer's disease (AD), pathological forms of tau are transferred from cell to cell and"
seed" aggregation of cytoplasmic tau. Phosphorylation of tau plays a key role in …

Alzheimer's disease (AD) is characterized by progressive accumulation of misfolded
proteins, which form senile plaques and neurofibrillary tangles, and the release of …

Recent evidence has shown that the processes of liquid-liquid phase separation (LLPS) or
liquid-liquid phase transitions (LLPTs) are a crucial and prevalent phenomenon that …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a
selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative …

The aggregation and accumulation of amyloidogenic peptides and proteins are observed as
pathological features in the brains of patients suffering from neurodegenerative disorders …