Overview of the 2022 WHO classification of neuroendocrine neoplasms

G Rindi, O Mete, S Uccella, O Basturk, S La Rosa… - Endocrine …, 2022 - Springer
In this review, we detail the changes and the relevant features that are applied to
neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and …

Updates in histopathological classification and tissue biomarkers of digestive neuroendocrine neoplasms: What the clinician should know

A Couvelard, A Cazes, J Cros - Best Practice & Research Clinical …, 2023 - Elsevier
Histopathological classifications of neuroendocrine neoplasms (NEN) change regularly and
the latest WHO classification published in 2022, which concerns all NEN in the body …

A pan-tissue DNA methylation atlas enables in silico decomposition of human tissue methylomes at cell-type resolution

T Zhu, J Liu, S Beck, S Pan, D Capper, M Lechner… - Nature …, 2022 - nature.com
Bulk-tissue DNA methylomes represent an average over many different cell types,
hampering our understanding of cell-type-specific contributions to disease development. As …

Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 …

WM Hackeng, LAA Brosens, JY Kim, R O'Sullivan… - Gut, 2022 - gut.bmj.com
Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …

Survival and incidence patterns of pancreatic neuroendocrine tumors over the last 2 decades: a SEER database analysis

MB Sonbol, GL Mazza, L Mi, T Oliver, J Starr… - The …, 2022 - academic.oup.com
Background Pancreatic neuroendocrine tumors (pNETs) are rare cancers with outcomes
determined by multiple factors including grade, stage, and clinical presentation. In this study …

[HTML][HTML] Gastrinoma

RT Jensen, T Ito - Endotext [Internet], 2023 - ncbi.nlm.nih.gov
Gastrinomas are neuroendocrine neoplasms (NENs), that occur primarily in the duodenum
and pancreas, which ectopically secrete gastrin, resulting in the Zollinger-Ellison syndrome …

Neuroendocrine neoplasms of the pancreas: diagnosis and pitfalls

B Konukiewitz, M Jesinghaus, A Kasajima, G Klöppel - Virchows Archiv, 2022 - Springer
Common to neuroendocrine neoplasms of the pancreas is their expression of
synaptophysin, chromogranin A, and/or INSM1. They differ, however, in their histological …

DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

V Lakis, RT Lawlor, F Newell, AM Patch… - Communications …, 2021 - nature.com
Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine
tumors (PanNETs) with associated clinical and genomic information. We identified three …

Treatment of advanced gastroenteropancreatic neuroendocrine neoplasia, are we on the way to personalised medicine?

A Rinke, CJ Auernhammer, L Bodei, M Kidd, S Krug… - Gut, 2021 - gut.bmj.com
Gastroenteropancreatic neuroendocrine neoplasia (GEPNEN) comprises clinically as well
as prognostically diverse tumour entities often diagnosed at late stage. Current classification …

Challenges and perspectives in computational deconvolution of genomics data

LX Garmire, Y Li, Q Huang, C Xu, SA Teichmann… - Nature …, 2024 - nature.com
Deciphering cell-type heterogeneity is crucial for systematically understanding tissue
homeostasis and its dysregulation in diseases. Computational deconvolution is an efficient …