Replication-dependent histones are expressed in a cell cycle regulated manner and supply
the histones necessary to support DNA replication. In mammals, the replication-dependent …

Simple Summary Urinary bladder cancer is one of the ten major cancers worldwide, with
higher incidences in males, in smokers, and in highly industrialized countries. New …

On-tissue digestion matrix-assisted laser desorption/ionization mass spectrometry imaging
(MALDI-MSI) can be used to record spatially correlated molecular information from formalin …

Phosphorylated H2AX (γ-H2AX) is a sensitive marker for DNA double-strand breaks (DSBs),
but the variability of H2AX expression in different cell and tissue types makes it difficult to …

Although many recent studies describe the emergence and prevalence of “clonal
hematopoiesis of indeterminate potential” in aged human populations, a systematic analysis …

Background Epigenetics research is progressing in basic, pre-clinical and clinical studies
using various model systems. Hence, updating the knowledge and integration of biological …

At the cellular level, cancer is the disease of both the genome and the epigenome, and the
interplay between genetic mutations and epigenetic states may occur at the level of …

Chagas disease, caused by Trypanosoma cruzi, still affects millions of people around the
world. No vaccines nor treatment for chronic Chagas disease are available, and …

In chronic lymphocytic leukemia (CLL), epigenetic alterations are considered to centrally
shape the transcriptional signatures that drive disease evolution and underlie its biological …

Proliferation and differentiation are controlled through chromatin remodelling. Therefore,
there is an enormous biological significance and clinical value in understanding how …