Transcriptome-wide association study of post-trauma symptom trajectories identified GRIN3B as a potential biomarker for PTSD development
Biomarkers that predict symptom trajectories after trauma can facilitate early detection or
intervention for posttraumatic stress disorder (PTSD) and may also advance our …
intervention for posttraumatic stress disorder (PTSD) and may also advance our …
IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder
Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share
dysregulated neuroimmune-related pathways. Here, we used our established rat model of …
dysregulated neuroimmune-related pathways. Here, we used our established rat model of …
Association of HLA locus alleles with posttraumatic stress disorder
Background Immune dysregulation has been widely observed in those with posttraumatic
stress disorder (PTSD). An individual's immune response is shaped, in part, by the highly …
stress disorder (PTSD). An individual's immune response is shaped, in part, by the highly …
Genomewide association study of alcohol dependence and related traits in a Thai population
Background Alcohol use (both quantity and dependence) is moderately heritable, and
genomewide association studies (GWAS) have identified risk genes in European, African …
genomewide association studies (GWAS) have identified risk genes in European, African …
Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways
Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of
PTSD following trauma is heritable, but robust common variants have yet to be identified by …
PTSD following trauma is heritable, but robust common variants have yet to be identified by …
Ethanol activates immune response in lymphoblastoid cells
JN McClintick, JA Tischfield, L Deng, M Kapoor, X Xuei… - Alcohol, 2019 - Elsevier
The short-term effects of alcohol on gene expression in brain tissue cannot directly be
studied in humans. Because neuroimmune signaling is altered by alcohol, immune cells are …
studied in humans. Because neuroimmune signaling is altered by alcohol, immune cells are …
Characterization of genomic regions escaping epigenetic reprogramming in sheep
CU Braz, MM Passamonti… - Environmental Epigenetics, 2024 - academic.oup.com
The mammalian genome undergoes two global epigenetic reprogramming events during
the establishment of primordial germ cells and in the pre-implantation embryo after …
the establishment of primordial germ cells and in the pre-implantation embryo after …
Methylation quantitative trait loci are largely consistent across disease states in Crohn's disease
Abstract Recently, we identified 1,189 CpG sites whose DNA methylation level in blood
associated with Crohn's disease. Here, we examined associations between DNA …
associated with Crohn's disease. Here, we examined associations between DNA …
Innate fear responses are reflected in the blood epigenome of rhesus macaques
H Bravo-Rivera, R Lardenoije, D Merced, A Mas-Rivera… - bioRxiv, 2020 - biorxiv.org
Fear and anxiety are complex physiological states aimed at promoting adaptive behaviors.
They are also core symptoms of many neuropsychiatric disorders; yet, our knowledge of the …
They are also core symptoms of many neuropsychiatric disorders; yet, our knowledge of the …
Improving diagnosis and characterization of Primary Aldosteronism through different-omics approaches
L Bertolone - 2020 - iris.univr.it
Primary aldosteronism (PA) is the most common form of secondary hypertension and it is
characterized by a Renin Angiotensin System (RAAS) independent overproduction of …
characterized by a Renin Angiotensin System (RAAS) independent overproduction of …