Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Aggressive leukemias arise in both children and adults as a result of rearrangements to the
mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large …

To assess the frequency of TP53 alterations and their correlation with other genetic changes
and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed …

Although quantitative PCR (qPCR) is becoming the method of choice for expression profiling
of selected genes, accurate and straightforward processing of the raw measurements …

Epigenetic dysregulation is a prominent feature in cancer, as exemplified by frequent
mutations in chromatin regulators, including the MLL/KMT2 family of histone …

Many sarcomas and leukemias carry nonrandom chromosomal translocations encoding
tumor-specific mutant fusion transcription factors that are essential to their molecular …

Cancer can be defined as a genetic disease, resulting as a consequence of multiple events
associated with initiation, promotion and metastatic growth. Cancer results from the loss of …

Rearrangements of the MLL gene, which is located at chromosome 11q23, are associated
with aggressive acute leukemias in both children and adults. MLL regulates Hox gene …

In all organisms, cell proliferation is orchestrated by coordinated patterns of gene
expression. Transcription results from the activity of the RNA polymerase machinery and …

Advances in our understanding of the pathophysiology of acute myeloid leukemia (AML)
have not yet led to major improvements in disease-free and overall survival of adults with …