Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms
E Garcia-Martin - Current drug metabolism, 2008 - ingentaconnect.com
Genetic polymorphisms of human arylamine N-acetyltransferase 2 (NAT2) are responsible
for interindividual variation in the acetylation of numerous drugs and in the transformation of …
for interindividual variation in the acetylation of numerous drugs and in the transformation of …
A homogenizing process of selection has maintained an “ultra-slow” acetylation NAT2 variant in humans
ABSTRACT N-Acetyltransferase 2 (NAT2) is an important enzyme involved in the
metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic …
metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic …
[HTML][HTML] Isoniazid acetylation phenotypes in the Sudanese population; findings and implications
MH Ali, AA Alrasheedy, D Kibuule, MA Hassali… - Journal of Clinical …, 2019 - Elsevier
Background Isoniazid (INH) is the mainstay antimicrobial in the treatment of tuberculosis
(TB). It is acetlylated in the liver to acetyl-INH. However, there is variation in rate of …
(TB). It is acetlylated in the liver to acetyl-INH. However, there is variation in rate of …
Human N-acetyltransferase 2 (NAT2) gene variability in Brazilian populations from different geographical areas
MQP Lopes, RLF Teixeira, PH Cabello… - Frontiers in …, 2023 - frontiersin.org
Introduction: Several polymorphisms altering the NAT2 activity have already been identified.
The geographical distribution of NAT2 variants has been extensively studied and has been …
The geographical distribution of NAT2 variants has been extensively studied and has been …
Influence of ethnicity on pharmacogenetic variation in the Ghanaian population
JL Yen-Revollo, DJ Van Booven, EJ Peters… - The …, 2009 - nature.com
It has been well established that the frequencies of genomic variants can vary greatly
between the populations of different countries. We sought to quantify the intra-population …
between the populations of different countries. We sought to quantify the intra-population …
Study on genotyping polymorphism and sequencing of N‐acetyltransferase 2 (NAT2) among Al‐Ahsa population
MA Zahra, M Kandeel, SA Aldossary… - BioMed Research …, 2020 - Wiley Online Library
One of the well‐studied phase II drug metabolizing enzymes is N‐acetyltransferase 2
(NAT2) which has an essential role in the detoxification and metabolism of several …
(NAT2) which has an essential role in the detoxification and metabolism of several …
[HTML][HTML] Evaluation of genetic polymorphisms of N-acetyltransferase 2 and relation with chronic myeloid leukemia
Objectives: The N-Acetyltransferase 2 (NAT2) gene encodes a key enzyme involved in
xenobiotic metabolism, which contributes to the detoxification of numerous cancer therapy …
xenobiotic metabolism, which contributes to the detoxification of numerous cancer therapy …
Age-distribution and genotype-phenotype correlation for N-acetyltransferase in Argentine children under isoniazid treatment.
GA Keller, L Fabian, M Gomez… - … journal of clinical …, 2014 - europepmc.org
Age-distribution and genotype-phenotype correlation for N-acetyltransferase in Argentine
children under isoniazid treatment. - Abstract - Europe PMC Sign in | Create an account …
children under isoniazid treatment. - Abstract - Europe PMC Sign in | Create an account …
[HTML][HTML] Impact of Pharmacogenetics Markers of Human NAT2 Gene in Tuberculosis Treatment
V Moraes-Silva, CA Dutra, MQP Lopes, PN Suffys… - 2024 - intechopen.com
Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, accounts for 10 million
cases worldwide per year, remaining a major problem for public health. The anti-TB drug …
cases worldwide per year, remaining a major problem for public health. The anti-TB drug …