INTRODUCTION: Recently, several reviews have been published on the effects of
medications on bone physiology and the clinical side effects in orthodontics. However, the …

During orthodontic tooth movement (OTM), alveolar bone is resorbed by osteoclasts in
compression sites (CS) and is deposited by osteoblasts in tension sites (TS). The aim of this …

Periodontal remodeling and alveolar bone resorption and formation play essential roles
during orthodontic tooth movement (OTM). In the process, human periodontal ligament cells …

Orthodontic tooth movement is achieved by mechanical loading; however, the biological
mechanism involved in this process is not clearly understood owing to the lack of a suitable …

Orthodontic tooth movement is dependent on osteoclast activity. Tumor necrosis factor (TNF)-
α plays an important role, directly or via chemokine release, in osteoclast recruitment and …

Orthodontic tooth movement (OTM) is associated with bone remodeling mediated by
orthodontic mechanical loading. Increasing studies reported that Wnt signaling played …

During orthodontic tooth movement, there is local production of chemokines and an influx of
leukocytes into the periodontium. CCL5 plays an important role in osteoclast recruitment and …

Previous studies revealed that cementum formation is tightly regulated by inorganic
pyrophosphate (PPi), a mineralization inhibitor. Local PPi concentrations are determined by …

Extensive histological study revealed the impairment of bone remodeling caused by
mechanical stress in OPN knockout mice in a tooth movement system. Analysis of OPN …

INTRODUCTION: The objective of this study was to evaluate the short-term effects of
clodronate, a first-generation bisphosphonate, on early alveolar bone remodeling and root …