Anemia of inflammation (AI), also known as anemia of chronic disease (ACD), is regarded
as the most frequent anemia in hospitalized and chronically ill patients. It is prevalent in …

Anemia and iron deficiency are important and common comorbidities that often coexist in
patients with heart failure. Both conditions, together or independently, are associated with …

Background Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that
stimulates erythropoiesis and regulates iron metabolism. Additional data are needed …

By following up the gut microbiome, 51 human phenotypes and plasma levels of 1,183
metabolites in 338 individuals after 4 years, we characterize microbial stability and variation …

Anemia is a frequent comorbidity of chronic kidney disease (CKD) and is associated with a
considerable burden because of decreased patient health-related quality of life and …

Anemia is a common feature of CKD associated with poor outcomes. The current
management of patients with anemia in CKD is controversial, with recent clinical trials …

A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …

Anemia of inflammation (AI) is a highly prevalent comorbidity in patients affected by chronic
inflammatory disorders, such as chronic kidney disease, inflammatory bowel disease, or …

Prolyl hydroxylase domain oxygen sensors are dioxygenases that regulate the activity of
hypoxia-inducible factor (HIF), which controls renal and hepatic erythropoietin production …

Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …