Pathogenetic mechanisms and treatment targets in cerebral malaria

A Hadjilaou, J Brandi, M Riehn, MA Friese… - Nature Reviews …, 2023 - nature.com
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

[HTML][HTML] Perspective: L-arginine and L-citrulline supplementation in pregnancy: a potential strategy to improve birth outcomes in low-resource settings

AM Weckman, CR McDonald, JAB Baxter… - Advances in …, 2019 - Elsevier
The available data support the hypothesis that L-arginine or L-citrulline supplementation
would be suitable for implementation in resource-constrained settings and will enhance …

[HTML][HTML] Roles and current applications of S-nitrosoglutathione in anti-infective biomaterials

H Qian, Z Ye, L Pi, J Ao - Materials Today Bio, 2022 - Elsevier
Bacterial infections can compromise the physical and biological functionalities of humans
and pose a huge economical and psychological burden on infected patients. Nitric oxide …

GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson's disease

L Jiao, LY Su, Q Liu, R Luo, X Qiao, T Xie… - Free Radical Biology …, 2022 - Elsevier
The S-nitrosoglutathione reductase (GSNOR) is a key denitrosating enzyme that regulates
protein S-nitrosation, a process which has been found to be involved in the pathogenesis of …

Improvement in outcomes after cardiac arrest and resuscitation by inhibition of S-nitrosoglutathione reductase

K Hayashida, A Bagchi, Y Miyazaki, S Hirai, D Seth… - Circulation, 2019 - Am Heart Assoc
Background: The biological effects of nitric oxide are mediated via protein S-nitrosylation.
Levels of S-nitrosylated protein are controlled in part by the denitrosylase, S …

Understanding the role of S-nitrosylation/nitrosative stress in inflammation and the role of cellular denitrosylases in inflammation modulation: Implications in health and …

A Chatterji, D Banerjee, TR Billiar… - Free Radical Biology and …, 2021 - Elsevier
S-nitrosylation is a very fundamental post-translational modification of protein and non-
protein thiols due the involvement of it in a variety of cellular processes including …

Cysteamine, an endogenous aminothiol, and cystamine, the disulfide product of oxidation, increase Pseudomonas aeruginosa sensitivity to reactive oxygen and …

DJ Fraser-Pitt, DK Mercer, D Smith… - Infection and …, 2018 - Am Soc Microbiol
Cysteamine is an endogenous aminothiol produced in mammalian cells as a consequence
of coenzyme A metabolism through the activity of the vanin family of pantetheinase …

Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor

JM Seckler, NM Meyer, ST Burton, JN Bates… - PLoS …, 2017 - journals.plos.org
Small molecule S-nitrosothiols are a class of endogenous chemicals in the body, which
have been implicated in a variety of biological functions. However, the labile nature of NO …

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria

VM Crowley, K Ayi, Z Lu, KT Liby, M Sporn, KC Kain - Malaria journal, 2017 - Springer
Background Cerebral malaria (CM) is a severe complication of Plasmodium falciparum
infection associated with high mortality and neurocognitive impairment in survivors. New anti …

Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei

S Torre, D Langlais, P Gros - Mammalian Genome, 2018 - Springer
Malaria is a common and sometimes fatal disease caused by infection with Plasmodium
parasites. Cerebral malaria (CM) is a most severe complication of infection with Plasmodium …