BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …

Fertility Preservation in Women | NEJM Skip to main content NEJM Group Follow Us Facebook
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The female germ line undergoes a unique sequence of differentiation processes that confers
totipotency to the egg,. The reconstitution of these events in vitro using pluripotent stem cells …

STUDY QUESTION Can complete oocyte development be achieved from human ovarian
tissue containing primordial/unilaminar follicles and grown in vitro in a multi-step culture to …

Approximately 10% of cancers occur in women under 45 years of age. Chemotherapy,
radiotherapy, and bone marrow transplantation cure more than 90% of cancer in women, but …

Summary The ISSCR Guidelines for Stem Cell Research and Clinical Translation were last
revised in 2016. Since then, rapid progress has been made in research areas related to in …

Background Oocyte growth is accompanied by follicular development in mammalian
ovaries. Since the discovery of two oocyte‐derived factors, growth differentiation factor 9 …

Meiosis is the chromosomal foundation of reproduction, with errors in this important process
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …

STUDY QUESTION Can a reconstructed ovary using decellularized human ovarian tissue
(DCT) support survival of pre-antral stage follicles? SUMMARY ANSWER We have …

The most immature oocytes remain dormant in primordial follicles in the ovary, ensuring the
longevity of female reproductive life. Despite its biological and clinical importance …