Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision
Cyclophosphamide (CP) is an important anticancer drug which belongs to the class of
alkylating agent. Cyclophosphamide is mostly used in bone marrow transplantation …
alkylating agent. Cyclophosphamide is mostly used in bone marrow transplantation …
Therapeutic potential and pharmaceutical development of thymoquinone: a multitargeted molecule of natural origin
Thymoquinone, a monoterpene molecule is chemically known as 2-methyl-5-isopropyl-1, 4-
benzoquinone. It is abundantly present in seeds of Nigella sativa L. that is popularly known …
benzoquinone. It is abundantly present in seeds of Nigella sativa L. that is popularly known …
Improvement of antihyperglycemic activity of nano-thymoquinone in rat model of type-2 diabetes
Thymoquinone is a bioactive constituent of Nigella sativa seeds. It has been reported to
possess antihyperglycemic effect in rats. However, the effect of nanoformulation (NF) of …
possess antihyperglycemic effect in rats. However, the effect of nanoformulation (NF) of …
Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling
This study evaluates the protective effects of Thymoquinone (Tq) and Curcumin (Cur) in
models of cisplatin-induced renal toxicity. Proliferation studies were carried out in HEK-293 …
models of cisplatin-induced renal toxicity. Proliferation studies were carried out in HEK-293 …
The Role of Antioxidants in Ameliorating Cyclophosphamide‐Induced Cardiotoxicity
MA Ayza, KA Zewdie, BA Tesfaye… - Oxidative Medicine …, 2020 - Wiley Online Library
The chemotherapeutic and immunosuppressive agent cyclophosphamide has previously
been shown to induce complications within the setting of bone marrow transplantation. More …
been shown to induce complications within the setting of bone marrow transplantation. More …
Ameliorative effect of thymoquinone and thymoquinone nanoparticles against diazinon-induced hepatic injury in rats: A possible protection mechanism
WM Nassar, WM El-Kholy, MR El-Sawi, NM El-Shafai… - Toxics, 2023 - mdpi.com
The health benefits of thymoquinone (TQ) have been a significant focus of numerous
studies. However, more research is needed to ascertain whether its nano-form can …
studies. However, more research is needed to ascertain whether its nano-form can …
Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway
Thymoquinone is a monoterpenoid compound, which is derived from volatile and fixed oil of
Nigella sativa (Ranunculaceae). This phytochemical compound has several biological …
Nigella sativa (Ranunculaceae). This phytochemical compound has several biological …
Therapeutic perspectives of the black cumin component thymoquinone: A review
The dietary phytochemical thymoquinone (TQ), belonging to the family of quinones, mainly
obtained from the black and angular seeds of Nigella sativa, is one of the promising …
obtained from the black and angular seeds of Nigella sativa, is one of the promising …
Methotrexate-loaded nanostructured lipid carrier gel alleviates imiquimod-induced psoriasis by moderating inflammation: formulation, optimization, characterization, in …
Introduction Methotrexate exhibits poor cutaneous bioavailability and systemic side effects
on topical administration, so there is an unmet need for a novel carrier and its optimized …
on topical administration, so there is an unmet need for a novel carrier and its optimized …
Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice
Incidence and prevalence of cancer is an alarming situation globally. For the treatment of
cancer many anticancer drugs have been developed but, unfortunately, their potential …
cancer many anticancer drugs have been developed but, unfortunately, their potential …