Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients
RP Silva-Aguiar, DB Peruchetti… - … of Physiology-Lung …, 2020 - journals.physiology.org
A new form of severe acute respiratory syndrome (SARS) caused by SARS-coronavirus 2
(CoV-2), called COVID-19, has become a global threat in 2020. The mortality rate from …
(CoV-2), called COVID-19, has become a global threat in 2020. The mortality rate from …
Antithrombotic potential of the contact activation pathway
AH Schmaier - Current opinion in hematology, 2016 - journals.lww.com
These investigations indicate that the proteins of the contact activation and kallikrein/kinin
systems influence thrombosis risk by several mechanisms and understanding of these …
systems influence thrombosis risk by several mechanisms and understanding of these …
Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and …
C Maier, I Schadock, PK Haber, J Wysocki… - Journal of Molecular …, 2017 - Springer
Prolylcarboxypeptidase (PRCP) is a carboxypeptidase that cleaves angiotensin II (AngII)
forming Ang (1–7). The impact of genetic PRCP deficiency on AngII metabolism, blood …
forming Ang (1–7). The impact of genetic PRCP deficiency on AngII metabolism, blood …
Prolylcarboxypeptidase Alleviates Hypertensive Cardiac Remodeling by Regulating Myocardial Tissue Angiotensin II
BY Nguyen, F Zhou, P Binder, W Liu… - Journal of the …, 2023 - Am Heart Assoc
Background Prolonged activation of angiotensin II is the main mediator that contributes to
the development of heart diseases, so converting angiotensin II into angiotensin 1‐7 has …
the development of heart diseases, so converting angiotensin II into angiotensin 1‐7 has …
[HTML][HTML] A Cross-sectional Study of KLKB1 and PRCP Polymorphisms in Patient Samples with Cardiovascular Disease
HR Gittleman, A Merkulova, O Alhalabi… - Frontiers in …, 2016 - frontiersin.org
Plasma kallikrein formed from prekallikrein (PK) produces bradykinin from kininogens and
activates factor XII. Plasma PK is activated by factors αXIIa, βXIIa, or prolylcarboxypeptidase …
activates factor XII. Plasma PK is activated by factors αXIIa, βXIIa, or prolylcarboxypeptidase …
Prolylcarboxypeptidase gene expression in the heart and kidney: Effects of obesity and diabetes
T Tabrizian, F Hataway, D Murray… - … Agents in Medicinal …, 2015 - ingentaconnect.com
Prolylcarboxypeptidase (PRCP) regulates plasma prekallikrein/high molecular weight
kininogen/bradykinin axis. It also modulates angiotensin II (Ang II), angiotensin III (Ang III) …
kininogen/bradykinin axis. It also modulates angiotensin II (Ang II), angiotensin III (Ang III) …
Relaxation induced by atrial natriuretic peptide is impaired in carotid but not renal arteries from spontaneously hypertensive rats due to reduced BKCa channel activity
T Matsumoto, S Watanabe, K Yamada… - Biological and …, 2015 - jstage.jst.go.jp
Atrial natriuretic peptide (ANP) plays an important role in vascular functions such as blood
pressure regulation and relaxant activity. Individual vascular beds exhibit differences in …
pressure regulation and relaxant activity. Individual vascular beds exhibit differences in …
Assessing adenoviral delivery of prolylcarboxypeptidase and extracellular vesicle-mediated delivery of angiotensin converting enzyme 2 as therapies in hypertensive …
AMA Alhajoj - 2024 - theses.gla.ac.uk
Cardiovascular diseases (CVD) are group of disorders that involve the heart and blood
vessels and are considered the main cause of death globally. Chronic activation of the …
vessels and are considered the main cause of death globally. Chronic activation of the …
Angiotensinase C mRNA and protein downregulations are involved in ethanol‐deteriorated left ventricular systolic dysfunction in spontaneously hypertensive rats
J Liu, A Hakucho, T Fujimiya - BioMed research international, 2015 - Wiley Online Library
The influences of angiotensinase C on ethanol‐induced left ventricular (LV) systolic function
were assessed in spontaneously hypertensive rats (SHRs). SHRs were fed by a liquid diet …
were assessed in spontaneously hypertensive rats (SHRs). SHRs were fed by a liquid diet …
Role of the renin angiotensin system in the development of severe COVID-19 in hypertensive patients 2
RM Rocco, AH Schmaier, P Machado, R e Silva… - journals.physiology.org
A new form of severe acute respiratory syndrome (SARS) caused by SARS-CoV-2, 21 called
COVID-19, has become a global threat in 2020. The mortality rate from COVID-22 19 is high …
COVID-19, has become a global threat in 2020. The mortality rate from COVID-22 19 is high …