Customizable manufacturing of ex vivo cell engineering is driven by the need for innovations
in the biomedical field and holds substantial potential for addressing current therapeutic …

We investigate how matrix stiffness regulates chromatin reorganization and cell
reprogramming and find that matrix stiffness acts as a biphasic regulator of epigenetic state …

Living organisms can detect and respond to physical forces at the cellular level. The
pathways that transmit these forces to the nucleus allow cells to react quickly and …

Polymerized β-actin may provide a structural basis for chromatin accessibility and actin
transport into the nucleus can guide mesenchymal stem cell (MSC) differentiation. Using …

The extracellular matrix (ECM) shapes the stem cell fate during differentiation by exerting
relevant biophysical cues. However, the mechanism of stem cell fate decisions in response …

The technology of induced pluripotent stem cells (iPSCs) has enabled the conversion of
somatic cells into primitive undifferentiated cells via reprogramming. This approach provides …

Cell reprogramming and manufacturing have broad applications in tissue regeneration and
disease treatment. However, many derived cell types lack unique cell surface markers for …

Cellular reprogramming technologies have been developed with different physicochemical
factors to improve the reprogramming efficiencies of induced pluripotent stem cells (iPSCs) …

Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including
mechanical forces and properties, are sensed and translated into biochemical signals …

The international AfroBiotech conference series, launched in 2019 in Atlanta, GA, USA, is an
emerging platform to foster innovation, promote inclusivity, and highlight the contributions of …