Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that
are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members …

Fibroblast growth factors (FGFs) comprise a large family of developmental and physiological
signaling molecules. All FGFs have a high affinity for the glycosaminoglycan heparin and for …

The fibroblast growth factors (FGFs) form a large family of structurally related, multifunctional
proteins that regulate various biological responses. They mediate cellular functions by …

We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the
FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 …

The Drosophila sugarless and sulfateless genes encode enzymes required for the
biosynthesis of heparan sulfate glycosaminoglycans. Biochemical studies have shown that …

Hospital-acquired bacterial infections are an increasingly important cause of morbidity and
mortality worldwide. Staphylococcal species are responsible for the majority of hospital …

This book provides basic principles of multivalent interactions found in biological systems as
well as an up-to-date and thorough coverage in design concepts, syntheses, and biological …

Heparin is a highly sulfated, linear polymer that participates in a plethora of biological
processes by interaction with many proteins. The chemical complexity and heterogeneity of …

A number of extracellular proteins contain cryptic inhibitors of angiogenesis. Endostatin is a
20 kDa C‐terminal proteolytic fragment of collagen XVIII that potently inhibits endothelial cell …

Recombinant mouse endostatin produced by mammalian cells was shown to bind to
heparin with a K d of 0.3 μM, suggesting that this interaction may play a role in its anti …