Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Microorganisms produce a wealth of structurally diverse specialized metabolites with a
remarkable range of biological activities and a wide variety of applications in medicine and …

Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial
metabolites, our knowledge of their diversity remains limited. Here, we used a novel …

The microbiota, and the genes that comprise its microbiome, play key roles in human health.
Host-microbe interactions affect immunity, metabolism, development, and behavior, and …

Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Burkholderia is an incredibly diverse and versatile Gram-negative genus, within which over
80 species have been formally named and multiple other genotypic groups likely represent …

Over the past decade, bacterial genome sequences have revealed an immense reservoir of
biosynthetic gene clusters, sets of contiguous genes that have the potential to produce drugs …