Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Tumor expression of prostate-specific membrane antigen (PSMA) is lost in 15–20% of men
with castration-resistant prostate cancer (CRPC), yet the underlying mechanisms remain …

Transcription factors (TFs) represent the most commonly deregulated DNA-binding class of
proteins associated with multiple human cancers. They can act as transcriptional activators …

PALI1 is a newly identified accessory protein of the Polycomb repressive complex 2 (PRC2)
that catalyzes H3K27 methylation. However, the roles of PALI1 in cancer are yet to be …

HOXB13 is a key lineage homeobox transcription factor that plays a critical role in the
differentiation of the prostate gland. Several studies have suggested that HOXB13 …

Direct identification of the proteins targeted by small molecules can provide clues for
disease diagnosis, prevention, and drug development. Despite concentrated attempts, there …

Glyphosate (Gly) is the most widely used herbicide with well-defined hepatotoxic effects, but
the underlying mechanisms of Gly-induced hepatic steatosis remain largely unknown. In this …

Prostate cancer is the second most common cancer in men in the United States, and racial
disparities are greatly observed in the disease. Specifically, African American (AA) patients …

Dysregulated lipid metabolism occurs in pathological processes characterized by cell
proliferation and migration. Nonetheless, the mechanism of increased mitochondrial lipid …

Abstract Background Advanced prostate cancer (PCa) will develop into castration-resistant
prostate cancer (CRPC) and lead to poor prognosis. As the primary subtype of CRPC …