AMPA receptors in Alzheimer disease: Pathological changes and potential therapeutic targets

L Ning, R Shen, B Xie, Y Jiang, X Geng… - … of Neuropathology & …, 2024 - academic.oup.com
Alzheimer disease (AD) is a prevalent neurodegenerative disorder that affects synapses and
leads to progressive cognitive decline. The role of N-methyl-D-aspartic acid (NMDA) …

[HTML][HTML] BDNF-TrkB signaling orchestrates the buildup process of local sleep

W ElGrawani, G Sun, FP Kliem, S Sennhauser… - Cell reports, 2024 - cell.com
Sleep debt accumulates during wakefulness, leading to increased slow wave activity (SWA)
during sleep, an encephalographic marker for sleep need. The use-dependent demands of …

Palmitoylation of synaptic proteins: roles in functional regulation and pathogenesis of neurodegenerative diseases

J Peng, D Liang, Z Zhang - Cellular & Molecular Biology Letters, 2024 - Springer
Palmitoylation is a type of lipid modification that plays an important role in various aspects of
neuronal function. Over the past few decades, several studies have shown that the …

[HTML][HTML] Knockout of AMPA receptor binding protein Neuron-Specific Gene 2 (NSG2) enhances associative learning and cognitive flexibility

AJ Zimmerman… - Molecular …, 2024 - molecularbrain.biomedcentral.com
The vast majority of gene mutations and/or gene knockouts result in either no observable
changes, or significant deficits in molecular, cellular, or organismal function. However, in a …

[HTML][HTML] Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion

MH Plitt, K Kaganovsky, TC Südhof, LM Giocomo - bioRxiv, 2023 - ncbi.nlm.nih.gov
Rapid delivery of glutamate receptors to the postsynaptic membrane via vesicle fusion is a
central component of synaptic plasticity. However, it is unknown how this process supports …

Tocotrienols Prevent the Decline of Learning Ability in High-Fat, High-Sucrose Diet-Fed C57BL/6 Mice

Y Kato, J Ben, A Noto, S Kashiwaya, Y Aoki… - International Journal of …, 2024 - mdpi.com
Obesity has been increasing worldwide and is well-known as a risk factor for cognitive
decline. It has been reported that oxidative stress in the brain is deeply involved in cognitive …

Glua1 Ubiquitination in Synaptic Plasticity and Cognitive Functions: Implications for Neurodegeneration

MI Hiskens - Journal of Neuroscience, 2024 - Soc Neuroscience
Learning and memory rely on processes involved in synaptic plasticity, such as long-term
potentiation (LTP) and long-term depression (LTD) of synaptic strength (Diering and …

Assessment of neuromodulatory effects of Origanum punonense danin essential oil on AMPA receptor function using whole-cell patch-clamp technique

M Qneibi, K Issa, A Bakhatan, MA Khaled, S Bdir… - European Journal of …, 2024 - Elsevier
Introduction: The quest for natural compounds with neuromodulatory properties has gained
significant momentum in neuropharmacology. Among these, Origanum punonense (O …

Electroacupuncture Alleviates Memory Deficits in APP/PS1 Mice by Targeting Serotonergic Neurons in Dorsal Raphe Nucleus

C Yu, X Wang, J Wang, C Li, J Xiao, X Wang… - Current Medical …, 2024 - Springer
Objective Alzheimer's disease (AD) has become a significant global concern, but effective
drugs able to slow down AD progression is still lacked. Electroacupuncture (EA) has been …

[HTML][HTML] Consequences of US COVID-19 Policy in 2024

CM Lepkowsky - Medical Research Archives, 2024 - esmed.org
COVID-19 is entering its fifth year as an active contagion. The evolution of the COVID-19
pandemic is explored with attention to epidemiology, virology, prevalence and prevalence …