The discovery of CD4+ T cell subset–defining master transcription factors and framing of the
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …

Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …

Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but
whether this interaction has physiological consequences on DC function is largely …

Host proteins are essential for HIV entry and replication and can be important nonviral
therapeutic targets. Large-scale RNA interference (RNAi)-based screens have identified …

B and T lymphocytes are the mediators of immunity, but their function is under the control of
dendritic cells. Dendritic cells in the periphery capture and process antigens, express …

Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells …

Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides,
and load these peptides onto major histocompatibility complex (MHC) class I and II …

Primary T-cell responses in lymph nodes (LNs) require contact-dependent information
exchange between T cells and dendritic cells (DCs). Because lymphocytes continually enter …

Glioblastomas (GBM) are the most frequent and aggressive malignant primary brain tumor
and remains a therapeutic challenge: even after multimodal therapy, median survival of …

Differentiation of naive CD4+ T cells into T helper (Th) cells is a defining event in adaptive
immunity. The cytokines and transcription factors that control Th cell differentiation are …