The immunopeptidome is the repertoire of peptides bound and presented by the MHC class
I, class II, and non-classical molecules. The peptides are produced by the degradation of …

The endolysosomal system comprises a dynamic constellation of vesicles working together
to sense and interpret environmental cues and facilitate homeostasis. Integrating …

Phagosomes are vesicles produced by phagocytosis of phagocytes, which are crucial in
immunity against Mycobacterium tuberculosis (Mtb) infection. After the phagocyte ingests the …

STING (also known as MITA) is an adaptor protein that mediates cytoplasmic DNA-triggered
signaling, and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function …

Resident tissue macrophages are organ-specialized phagocytes responsible for the
maintenance and protection of tissue homeostasis. It is well established that tissue diversity …

Ubiquitination is a post-translational modification that plays essential roles in various
physiological and pathological processes. Protein ubiquitination depends on E3 ubiquitin …

Phagosome acidification and proteolysis are essential processes in the immune response to
contain and eliminate pathogens. In recent years, there has been an increased desire for a …

The E3 ubiquitin ligase RING finger protein 115 (RNF115), also known as breast cancer-
associated gene 2 (BCA2), has been linked with the growth of some cancers and immune …

The engulfment of “self” and “non-self” particles by immune and non-immune cells is crucial
for maintaining homeostasis and combatting infection. Engulfed particles are contained …

Phagosome acidification and proteolysis are essential processes in the immune response to
contain and eliminate pathogens. In recent years, there has been an increased desire for a …