Advances in islet encapsulation technologies
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …
Stem cell therapies for treating diabetes: progress and remaining challenges
Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …
diabetes research and therapy. While whole-organ and islet transplantation have become …
Hydrogels in emerging technologies for type 1 diabetes
Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …
painless manner for patients has remained a central focus of next-generation diabetes …
A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells
The long-term function of transplanted therapeutic cells typically requires systemic immune
suppression. Here, we show that a retrievable implant comprising a silicone reservoir and a …
suppression. Here, we show that a retrievable implant comprising a silicone reservoir and a …
[HTML][HTML] Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus
PO Carlsson, D Espes, A Sedigh, A Rotem… - American Journal of …, 2018 - Elsevier
Macroencapsulation devices provide the dual possibility of immunoprotecting transplanted
cells while also being retrievable, the latter bearing importance for safety in future trials with …
cells while also being retrievable, the latter bearing importance for safety in future trials with …
Transplantation of human islets without immunosuppression
B Ludwig, A Reichel, A Steffen… - Proceedings of the …, 2013 - National Acad Sciences
Transplantation of pancreatic islets is emerging as a successful treatment for type-1
diabetes. Its current stringent restriction to patients with critical metabolic lability is justified …
diabetes. Its current stringent restriction to patients with critical metabolic lability is justified …
Biomanufacturing for clinically advanced cell therapies
The achievements of cell-based therapeutics have galvanized efforts to bring cell therapies
to the market. To address the demands of the clinical and eventual commercial-scale …
to the market. To address the demands of the clinical and eventual commercial-scale …
Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond
M Farina, JF Alexander, U Thekkedath, M Ferrari… - Advanced drug delivery …, 2019 - Elsevier
Cell-based therapy is emerging as a promising strategy for treating a wide range of human
diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and …
diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and …
Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression
Cellular therapies for type-1 diabetes can leverage cell encapsulation to dispense with
immunosuppression. However, encapsulated islet cells do not survive long, particularly …
immunosuppression. However, encapsulated islet cells do not survive long, particularly …
[HTML][HTML] Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease characterized by
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …