Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the
immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent …

Naturally occurring regulatory T (nTreg) cells, which specifically express the transcription
factor Forkhead box protein P3 (FoxP3), are indispensable for the maintenance of …

Adaptive immune responses are tailored to different types of pathogens through
differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T …

The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells,
yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that …

We have recently identified T cells as important mediators of ischemic brain damage, but the
contribution of the different T-cell subsets is unclear. Forkhead box P3 (FoxP3)–positive …

Regulatory T cells (Treg cells) develop from progenitor thymocytes after the engagement of
T cell antigen receptors (TCRs) with high-affinity ligands, but the underlying molecular …

Tumor-bearing individuals have been reported to harbor increased numbers of Foxp3+
regulatory T cells (Treg), which prevent the development of efficient antitumor immune …

Regulatory T (Treg) cells contribute to immune homeostasis but suppress immune
responses to cancer. Strategies to disrupt Treg cell–mediated cancer immunosuppression …

Asthma is a chronic inflammatory airway disease involving complex interplay between
resident and infiltrative cells, which in turn are regulated by a wide range of host mediators …

Regulatory T cells (Treg cells) are essential for self-tolerance and immune homeostasis.
Lack of effector T cell (Teff cell) function and gain of suppressive activity by Treg cells are …