Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Zinc is the second abundant trace element in the human central nervous system (CNS). Zinc
homeostasis is impaired in the elderly population and Alzheimer's disease (AD) patients …

Conformational changes of Aβ peptide result in its transformation from native monomeric
state to the toxic soluble dimers, oligomers and insoluble aggregates that are hallmarks of …

Metal chelation can provide structural stability and form reactive centers in metalloproteins.
Approximately one third of known protein structures are metalloproteins, and metal binding …

Alzheimer's disease (AD) is the most common form of dementia, where one of the
pathological hallmarks of AD is extracellular protein deposits, the primary component of …

Clinical studies suggest that traumatic brain injury (TBI) hastens cognitive decline and
development of neuropathology resembling brain aging. Blood–brain barrier (BBB) …

A hallmark of Alzheimer's disease (AD) are the proteinaceous aggregates formed by the
amyloid-beta peptide (Aβ) that is deposited inside the brain as amyloid plaques. The …

Childhood lead poisoning is a costly and largely preventable public health problem that
lowers IQs, decreases attention spans, and leads to the development of other childhood …

Drug development for the treatment of Alzheimer's disease (AD) has been for a long time
focused on agents that were expected to support endogenous β-amyloid (Aβ) in a …