Neuroinflammation has positive and negative effects. This review focuses on the roles of
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …

Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the
gold standard autograft) and its main clinically approved alternative—hollow nerve guidance …

Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …

Axon regeneration in the mature mammalian central nervous system (CNS) is extremely
limited after injury. Consequently, functional deficits persist after spinal cord injury (SCI) …

Peripheral nerves regenerate following injury due to the effective activation of the intrinsic
growth capacity of the neurons and the formation of a permissive pathway for outgrowth due …

Macrophages have been implicated in peripheral nerve regeneration for some time,
supposedly through their involvement in Wallerian degeneration, the process by which the …

Activating transcription factor 3 (ATF3) belongs to the ATF/cyclic AMP responsive element
binding family of transcription factors and is often described as an adaptive response gene …

Peripheral nerve injury is normally followed by a robust regenerative response. Here we
describe the early changes associated with injury from the initial rise in intracellular calcium …

Glial cells are established as essential for many functions of the central nervous system, and
this seems to hold also for glial cells in the peripheral nervous system. The main type of glial …

Unlike its central counterpart, the peripheral nervous system is well known for its
comparatively good potential for regeneration following nerve fiber injury. This ability is …