Emerging roles of lipids in BCL-2 family-regulated apoptosis
T Zhang, A Saghatelian - Biochimica et Biophysica Acta (BBA)-Molecular …, 2013 - Elsevier
Apoptosis is an intricately regulated process required for the health and homeostasis of
living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro …
living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro …
[HTML][HTML] On the role of lipid in colicin pore formation
SD Zakharov, EA Kotova, YN Antonenko… - Biochimica et Biophysica …, 2004 - Elsevier
Insights into the protein–membrane interactions by which the C-terminal pore-forming
domain of colicins inserts into membranes and forms voltage-gated channels, and the …
domain of colicins inserts into membranes and forms voltage-gated channels, and the …
[HTML][HTML] Effect of lipids with different spontaneous curvature on the channel activity of colicin E1: evidence in favor of a toroidal pore
AA Sobko, EA Kotova, YN Antonenko, SD Zakharov… - FEBS letters, 2004 - Elsevier
The channel activity of colicin E1 was studied in planar lipid bilayers and liposomes. Colicin
E1 pore-forming activity was found to depend on the curvature of the lipid bilayer, as judged …
E1 pore-forming activity was found to depend on the curvature of the lipid bilayer, as judged …
Lipid dependence of the channel properties of a colicin E1-lipid toroidal pore
AA Sobko, EA Kotova, YN Antonenko… - Journal of Biological …, 2006 - ASBMB
Colicin E1 belongs to a group of bacteriocins whose cytotoxicity toward Escherichia coli is
exerted through formation of ion channels that depolarize the cytoplasmic membrane. The …
exerted through formation of ion channels that depolarize the cytoplasmic membrane. The …
Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis
Upon apoptotic stimuli, lysosomal proteases, including cathepsins and chymotrypsin, are
released into cytosol due to lysosomal membrane permeabilization (LMP), where they …
released into cytosol due to lysosomal membrane permeabilization (LMP), where they …
Permeabilization of the outer mitochondrial membrane by Bcl-2 proteins
AJ García-Sáez, G Fuertes, J Suckale… - … Membrane Binding and …, 2010 - Springer
T he proteins of the Bcl-2 family regulate the release of the apoptotic factors from
mitochondria during apoptosis, a key event in physiological cell death. Although their …
mitochondria during apoptosis, a key event in physiological cell death. Although their …
On the mechanism of membrane permeabilization by tamoxifen and 4-hydroxytamoxifen
J Ortiz, JA Teruel, FJ Aranda, A Ortiz - Membranes, 2023 - mdpi.com
Tamoxifen (TMX), commonly used in complementary therapy for breast cancer, also displays
known effects on the structure and function of biological membranes. This work presents an …
known effects on the structure and function of biological membranes. This work presents an …
Distinct mechanisms of membrane permeation induced by two polymalic acid copolymers
Anionic polymers are valuable components used in cosmetics and health sciences,
especially in drug delivery, because of their chemical versatility and low toxicity. However …
especially in drug delivery, because of their chemical versatility and low toxicity. However …
Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathway
Lysosomes can trigger the mitochondrial apoptotic pathway by releasing proteases. Here
we report that a 25-kDa protein purified from rat liver lysosomes possesses a long standing …
we report that a 25-kDa protein purified from rat liver lysosomes possesses a long standing …
Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid
We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored
in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the …
in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the …