Apoptosis is an intricately regulated process required for the health and homeostasis of
living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro …

Insights into the protein–membrane interactions by which the C-terminal pore-forming
domain of colicins inserts into membranes and forms voltage-gated channels, and the …

The channel activity of colicin E1 was studied in planar lipid bilayers and liposomes. Colicin
E1 pore-forming activity was found to depend on the curvature of the lipid bilayer, as judged …

Colicin E1 belongs to a group of bacteriocins whose cytotoxicity toward Escherichia coli is
exerted through formation of ion channels that depolarize the cytoplasmic membrane. The …

Upon apoptotic stimuli, lysosomal proteases, including cathepsins and chymotrypsin, are
released into cytosol due to lysosomal membrane permeabilization (LMP), where they …

T he proteins of the Bcl-2 family regulate the release of the apoptotic factors from
mitochondria during apoptosis, a key event in physiological cell death. Although their …

Tamoxifen (TMX), commonly used in complementary therapy for breast cancer, also displays
known effects on the structure and function of biological membranes. This work presents an …

Anionic polymers are valuable components used in cosmetics and health sciences,
especially in drug delivery, because of their chemical versatility and low toxicity. However …

Lysosomes can trigger the mitochondrial apoptotic pathway by releasing proteases. Here
we report that a 25-kDa protein purified from rat liver lysosomes possesses a long standing …

We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored
in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the …