Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …

Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …

The major health-care burden for the developing world are infectious diseases where
antimicrobial agents prove to be the magical drugs to combat this. But the phenomenon of …

Background Multidrug-resistant tuberculosis (MDR-TB) poses a serious challenge to TB
control. It is of great value to search for drug resistance mutation sites and explore the roles …

Abstract According to the World Health Organization (WHO), tuberculosis is the leading
cause of death attributed to a single microbial pathogen worldwide. In addition to the large …

The emergence and persistence of drug-resistant tuberculosis is a major threat to global
public health. Our objective was to assess the applicability of whole-genome sequencing …

Molecular methods detect genetic mutations associated with drug resistance. This study
detected resistance-conferring mutations in gyrA/gyrB for fluoroquinolones and rrs/eis genes …

We assessed the performance of MTBDRsl for detection of resistance to fluoroquinolones,
aminoglycosides/cyclic peptides, and ethambutol compared to BACTEC MGIT 960 by …

The clinical complexity of co-managing drug-resistant TB and HIV, and the higher rate of
poor treatment outcomes in this population demand careful clinical management strategies …

Objective To detect levofloxacin (LFX) and moxifloxacin (MFX) resistance among rifampicin-
resistant tuberculosis (RR-TB) isolates, and predict the resistance level based on specific …