The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, has
increased in incidence and prevalence in recent decades. Both clinical and animal studies …

K+ channels are involved in many critical functions in lung physiology. Recently, the family
of Ca2+-activated K+ channels (KCa) has received more attention, and a massive amount of …

TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …

Bicarbonate secretion is a fundamental process involved in maintaining acid-base
homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in …

Acute respiratory distress syndrome (ARDS) is characterized by an exacerbated
inflammatory response, severe damage to the alveolar-capillary barrier and a secondary …

Mucosa-associated biofilms are associated with many human disease states, but the host
mechanisms promoting biofilm remain unclear. In chronic respiratory diseases like cystic …

Background and Purpose Acute respiratory distress syndrome (ARDS) is characterized by
pulmonary oedema and severe hypoxaemia. We investigated whether genetic deficit or …

Based on its role in fibrosis, inflammation and mitochondrial dysfunction, pharmacological
inhibition of KCa3. 1 may offer a promising alternative for the treatment of DKD. Due to its …

Mucosa-associated biofilms are associated with many human disease states, but the
mechanisms by which the host promotes biofilm biogenesis remain unclear. In chronic …