Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …

Acute respiratory distress syndrome (ARDS) is defined as a syndrome of acute onset, with
bilateral opacities on chest imaging and respiratory failure not caused by cardiac failure …

Platelets are small circulating anucleate cells that are of crucial importance in haemostasis.
Over the last decade, it has become increasingly clear that platelets play an important role in …

There is increasing recognition that platelets have a functional role in the pathophysiology of
sepsis, though this role has not been precisely defined. Whether sepsis alters the human …

Platelets are chief effector cells in hemostasis. In addition, however, their specializations
include activities and intercellular interactions that make them key effectors in inflammation …

The inflammasomes control the bioactivity of pro-inflammatory cytokines of the interleukin
(IL)-1 family. The inflammasome assembled by NLRP3 has been predominantly studied in …

Thrombocytopenia is a common finding in sepsis and associated with a worse outcome. We
used a mouse model of pneumonia-derived sepsis caused by the human pathogen …

The caspase family of cysteine proteases becomes activated in response to diverse cellular
insults and coordinates apoptosis through proteolysis of hundreds of cellular substrates …

Besides mediating primary hemostasis and thrombosis, platelets play a critical role in tissue
repair and regeneration. They regulate fundamental mechanisms involved in the healing …

Megakaryocytes (MKs) are responsible for platelet biogenesis, which is believed to occur
canonically in adult bone marrow (BM) and in the fetal liver during development. However …