The somatostatin-secreting δ-cells comprise~ 5% of the cells of the pancreatic islets. The δ-
cells have complex morphology and might interact with many more islet cells than …

The pancreatic islet is a dense cellular network comprised of several cell types with
endocrine function vital in the control of glucose homeostasis, metabolism, and feeding …

Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …

Generation of beta cells via transdifferentiation of other cell types is a promising avenue for
the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and …

Objective Histone deacetylases are epigenetic regulators known to control gene
transcription in various tissues. A member of this family, histone deacetylase 3 (HDAC3), has …

Air pollution involving particulate matter smaller than 2.5 μm in size (PM2. 5) is the world's
leading environmental risk factor contributing to mortality through cardiometabolic pathways …

Objective Hyperglycemia and systemic inflammation, hallmarks of Type 2 Diabetes (T2D),
can induce the production of the inflammatory signaling molecule Prostaglandin E 2 (PGE 2) …

Background RGS protein family members have recently became new potentially promising
therapeutic targets in many cancers. However, as a key member of RGS family, RGS16 has …

Type 1 Diabetes (T1D) occurs as a result of the autoimmune destruction of pancreatic β-cells
by self-reactive T cells. The etiology of this disease is complex and difficult to study due to a …