Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review

N Esplen, MS Mendonca… - Physics in Medicine & …, 2020 - iopscience.iop.org
Ultrahigh dose-rate radiotherapy (RT), or'FLASH'therapy, has gained significant momentum
following various in vivo studies published since 2014 which have demonstrated a reduction …

FLASH: New intersection of physics, chemistry, biology, and cancer medicine

MC Vozenin, BW Loo Jr, S Tantawi, PG Maxim… - Reviews of Modern …, 2024 - APS
Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …

Understanding high-dose, ultra-high dose rate, and spatially fractionated radiation therapy

RJ Griffin, MM Ahmed, B Amendola, O Belyakov… - International Journal of …, 2020 - Elsevier
The National Cancer Institute's Radiation Research Program, in collaboration with the
Radiosurgery Society, hosted a workshop called Understanding High-Dose, Ultra-High …

Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model

LML Smyth, JF Donoghue, JA Ventura, J Livingstone… - Scientific reports, 2018 - nature.com
Synchrotron radiation can facilitate novel radiation therapy modalities such as microbeam
radiation therapy (MRT) and high dose-rate synchrotron broad-beam radiation therapy …

A global analysis of viviparity in squamates highlights its prevalence in cold climates

A Zimin, SV Zimin, R Shine, L Avila… - Global Ecology and …, 2022 - Wiley Online Library
Aim Viviparity has evolved more times in squamates than in any other vertebrate group;
therefore, squamates offer an excellent model system in which to study the patterns, drivers …

[HTML][HTML] Microbeam radiation therapy: Clinical perspectives

MA Grotzer, E Schültke, E Bräuer-Krisch, JA Laissue - Physica Medica, 2015 - Elsevier
Microbeam radiation therapy (MRT), a novel form of spatially fractionated radiotherapy (RT),
uses arrays of synchrotron-generated X-ray microbeams (MB). MRT has been identified as a …

FLASH and minibeams in radiation therapy: the effect of microstructures on time and space and their potential application to protontherapy

A Mazal, Y Prezado, C Ares, L de Marzi… - The British Journal of …, 2020 - academic.oup.com
After years of lethargy, studies on two non-conventional microstructures in time and space of
the beams used in radiation therapy are enjoying a huge revival. The first effect called …

[HTML][HTML] Effects of microbeam radiation therapy on normal and tumoral blood vessels

A Bouchet, R Serduc, JA Laissue, V Djonov - Physica Medica, 2015 - Elsevier
Microbeam radiation therapy (MRT) is a new form of preclinical radiotherapy using quasi-
parallel arrays of synchrotron X-ray microbeams. While the deposition of several hundred …

Microbeam radiation therapy—grid therapy and beyond: a clinical perspective

E Schültke, J Balosso, T Breslin… - The British journal of …, 2017 - academic.oup.com
Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam
irradiation with therapeutic intent has become known as microbeam radiation therapy …

A matter of space: how the spatial heterogeneity in energy deposition determines the biological outcome of radiation exposure

G Baiocco, S Bartzsch, V Conte, T Friedrich… - Radiation and …, 2022 - Springer
The outcome of the exposure of living organisms to ionizing radiation is determined by the
distribution of the associated energy deposition at different spatial scales. Radiation …